Dr. Shi is an Associate Professor at Harvard Medical School, and a faculty member in the Center for Nanomedicine and Department of Anesthesiology at Brigham and Women’s Hospital. His lab is interested in basic and applied science in the field of nanomedicine. His research involves a highly interdisciplinary combination of nanotechnology, biomaterials, drug delivery, immunotherapy, and antioxidative therapy for biomedical applications in cancer, atherosclerosis, and other diseases. He has developed various nanoparticle platforms for effective delivery of therapeutics ranging from small molecules to RNAs and proteins. Notably, the immunonanotherapeutics developed by him and colleagues using self-assembled polymeric nanoparticles has resulted in the clinical trials of synthetic nanoparticle vaccines for different diseases. His current research focuses include: i) RNAi nanotechnology for gene silencing; ii) mRNA delivery for restoration of tumor suppressors; and iii) development of stimuli-responsive nanomaterials and bioinspired antioxidative polymers. He has also received the K99/R00 Career Development Award from National Institutes of Health, the Young Investigator Award and the Movember Challenge Award from Prostate Cancer Foundation, the Lung Cancer Discovery Award from American Lung Association, and other awards.